Endocrine Abstracts

Previous studies have demonstrated over-expression of cyclooxygenase-2 (COX-2) enzyme and enhanced synthesis of prostanoids, such as prostaglandin E2 (PGE2), in cervical carcinomas. PGE2 mediates its is effects by interacting with one of four receptors termed EP1-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical carcinomas. We have previously proposed that in addition to endogenous PGE2, EP recepto...